2-DG or 2-deoxy-D-glucose is helpful for COVID-19 or Coronavirus Treatment

 2-DG or 2-deoxy-D-glucose is helpful for COVID-19 or Coronavirus Treatment 

 

2-DG and COVID-19 Treatment || Is 2-DG is helpful for COVID-19 treatment?

 

Highlights of the topic:

·          What is 2-Deoxy-D-glucose or 2-DG?

·          Can all COVID-19 patients use 2-deoxy-D-glucose?

·          Clinical Trials of 2-deoxy-D-glucose and accuracy of vaccine

·          Chemical and Physical Properties of 2-Deoxy-D-glucose or 2-DG

·          Mechanism of Action of 2-DG against SARS-CoV-2 or corona-virus:

·          Use of 2-Deoxy-D-glucose or 2-DG in COVID-19 treatment.

·          Dose of medication of 2-deoxy-D-glucose  for COVID-19 patients

·          Available form 2-DG.

 

What is 2-Deoxy-D-glucose or 2-DG?

2-DG is a glucose molecule in which the 2-hydroxyl group (OH) substituted by hydrogen (H) so that it cannot undertake further glycolysis. It helps competitively to prevent the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level of the glycolysis process. Its other names are 2-Deoxyglucose, 2-Deoxy-d-mannose, 2-Deoxy-d-arabino-hexose, 2-DG.

Although no new anti-COVID medications are available in India or internationally, medications such as Remdesivir, Tocilizumab, Steroid drugs, Ivermectin, Hydroxychloroquine (until last year), and Dexamethasone are being reconfigured for use in taming the effects of the virus. Moreover, their utilization and affordability have been called into question in recent days. In this situation, researchers believe that the 2-deoxy-D-glucose, therapeutic COVID compound is much superior to the repurposed medications.

                                              

2-Deoxy-D-glucose

Chemical and Physical Properties of 2-Deoxy-D-glucose or 2-DG

                                                         

Sr.No	Property	Value
1.	Chemical formula	C6H12O5
2.	Molecular Weight	164.16
3.	Melting Point	147°C (296.6°F)
4.	Formal Charge	0
5.	Hydrogen Bond Donor Count	4
6.	Hydrogen Bond Acceptor Count	5

 

 Mechanism of Action of 2-DG against SARS-CoV-2 or Coronavirus:

2-Deoxy-D-glucose or 2-DG is up engaged by the glucose transporters of the cell. As a result, cells with higher glucose uptake, for example, tumor cells or virus-affected cell, have also a higher uptake of 2-DG or 2-Deoxy-D-glucose. 2-DG or 2-Deoxy-D-glucose is a glucose analog molecule, which looks like a glucose molecule but it is not glucose. A virus or bacteria that are reproducing fast in the body needs glucose for energy. Thus, the virus or bacteria will take this glucose analog and will get arrested or stop multiplying. This is how this drug will help to stop the virus from multiplying in the body of an organism.

 

Use of 2-Deoxy-D-glucose or 2-DG in COVID-19 treatment

As we know in the above paragraph that 2-Deoxy-D-glucose or 2-DG will help to  stop the virus from multiplying in the body of any organism. On May 8, 2021, the Drugs Controller General of India approved 2-Deoxy-D-glucose or 2-DG an anti-COVID oral drug, developed institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, a lab of the Defense Research and Development Organization, in collaboration with Hyderabad-based pharma company Dr. Reddy’s Laboratories for emergency use as an adjunct therapy in moderate-to-severe coronavirus patients. In the clinical trials, data suggest that the drug is effective in cutting oxygen dependence. It was experimental that the 2-deoxy-D-glucose (2-DG) molecule works efficiently against the SARS-CoV-2 virus and inhibits viral growth.

Clinical Trials of 2-deoxy-D-glucose and accuracy of vaccine

Based on each of these results, the Drugs Controller General of India's (DCGI) Central Drugs Standard Control Organization (CDSCO) has approved a Phase II clinical trial of 2-DG in COVID-19 patients beginning in May 2020. The DRDO and its business partner DRL, Hyderabad, have started clinical trials to evaluate the drug's safety and efficacy in COVID-19 patients. The drug was shown to be stable in COVID-19 patients and demonstrated substantial progress in their rehabilitation in Phase-II experiments (including dose-ranging) performed between May and October 2020. The Phase II clinical trial was carried out in six hospitals, and the Phase IIb (dose-ranging) clinical trial was carried out in 11 hospitals around the world. A phase-II experiment of 110 clinicians was carried out.

 

Can all COVID-19 patients use 2-deoxy-D-glucose?

Currently, the medication is only approved for use in mild to extreme COVID-19 situations. Patients with minor infections that are healing at home do not need the opioid and can safely heal at home if proper procedures are followed. Know that, like many others, this is also an experimental drug with emergency use approval. The continued use of the medication (or any other drug), as well as stockpiling stocks, without prior approval by the prescribing doctor, would only lead to complications

Dose of medication of 2-deoxy-D-glucose for COVID-19 patients

The medicine, which is being co-manufactured by Dr. Reddy's Laboratories, has yet to be priced. However, the price will be kept affordable, and the first 10,000 doses will be distributed to us this week. The 2DG medication should be taken orally, dissolved in water, twice a day. Patients with COVID-19 can need to continue this medication for 5-seven days to fully prevent virus progress.

The available form of 2-deoxy-D-glucose  

2-deoxy-D-glucose (2-DG) comes in a powdered. Like normal glucose powder, this drug can be taken with water, twice a day or as prescribed by doctor.

 

Side effects:  Not reported so far